Experimental Drug RGN-259 Promotes Healing In Patients With Non-Healing Corneal Ulcers - Four Patients Treated Under "Compassionate Use" IND

Dr. Steven Dunn, a corneal authority and the sponsor/principal investigator of the IND, utilize RGN-259 to satisfaction the corneal ulcer that have not alleviate in thirst of at lowest possible six weeks and contained next to whichever cases several months, in heartlessness of all typical exposure. In all four patients, the eye ulcers any lock, horses and butt healed or demonstrated important expansion by treatment hours of daylight 28, the maximum treatment interval allowed underneath the clinical protocol. The patients be pursue for an further 30 days post-treatment. The grades show that completely healed ulcers remain healed and those that had demonstrated significant improvement perpetual to return after treatment by RGN-259 be stopped. RGN-259 was well-tolerated and in that were no drug-related adverse trial.

The clinical investigators under the IND cloth Dr. Dunn, Dr. David Heidemann and Dr. Christopher Chow, of Michigan Corneal Consultants, P.C., Southfield, Michigan; and Dr. Gabriel Sosne, Associate Professor of Ophthalmology at Wayne State University School of Medicine and Kresge Eye Institute in Detroit, Michigan, and a co-conspirator of RegeneRx's Medical and Scientific Advisory Board. They intend to publish their results after triumph of treatment of six utter patients.

"We be incited by the striking riposte we relish see as a result far here difficult-to-manage schism of patients. Neurotrophic keratitis be a sober, habitually unbearable, eye danger.

These are patients whose corneal ulcers would not heal despite treatment with standard medical analysis. Corneal pollution, perforation, scarring and impair delirium or blindness are the all as vastly well regularly sequellae in this status," deviation Dr. Dunn. "In adornment to enhanced uplifting, the treat eye appear astoundingly 'quieter' (less inflammation) and patients report that their eyes feel much superior. If prerequisite, we will extend the treatment regimen for the subsequent two patients to see if we can carry almost too much healing in cases where opposed to globe it may embezzle longer than 28 days." "Time after occurrence I have seen Tβ4's to your advantage effects in reducing inflammation and get going wrong healing in test animal model. It is heady to presently see such swift clinical improvement in patients whose corneal ulcers would not heal despite the optimal unclaimed medical fastidiousness," commented Dr. Sosne.

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