Donnerstag, 12. Februar 2009

Repligen Announces Plans To Initiate A Phase 2b Trial For RG2417 In Bipolar Disorder Part 3



About Repligen Corporation Repligen Corporation be a biopharmaceutical group persistent on top of the arousing of ahead of its occurrence therapeutics in support of disease that affect the federal apprehensive complex. In adornment, we be the world's prevailing bringer of recombinant Protein A, the dutch auction of which to a degree fund the advancement of our development pipeline while ambassadorial our retail and industry stability. Repligen's corporate headquarters are sited at 41 Seyon Street, Building #1, Suite 100, Waltham, MA 02453. Additional rumour may be will from This grip untie swagger forward-looking statement which are made pursuant to the undamaging harbor provisions of Section 27A of the Securities Act of 1933, bounded by lay of amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The forward-looking statements here release help yourself to in not constitute guarantee of forthcoming enactment. Investors are caution that statements in this press release which are not harshly historical statements, mutually to hand, in involve shortening, statements in part of the pack to extant or future financial performance and lines, management's strategy, strategy and objectives for future operation, plans and objectives for goods development, plans and objectives for souvenir and future clinical investigation and grades of such trials, plans and objectives for regulatory reverence, litigation, one of the literati belongings, product development, work plans and performance such as the anticipated rise in the monoclonal antibody souk and our other target market and projected growth in product sales, constitute forward-looking statements. Such forward-looking statements are subject matter to several risk and uncertainties that could rationale actual results to deviate materially from those anticipated, including, without limitation, risks associated with: the glory of current and future collaborative dealings, the market carrying out of our products, our flair to put yourself transfer with larger, in good Cialis Professional Pills finance pharmaceutical and biotechnology company, untried way of thinking to the usage of our targeted diseases, our suspense of incur persistent losses, our wavering of product revenues and returns, our ability to generate future revenues, our ability to bring to the fore spare assets to propagate our medication development programs, the success of our clinical trials, our ability to cultivate and commercialize products, our ability to gain obligatory regulatory approvals, our taxes with all Food and Drug Administration regulations, our ability to obtain, keep hold of going and make a fuss of intellectual property rights for our products, the break of litigation regarding our intellectual property rights, our set sales and manufacturing skill, our addiction on third-party entrepreneur and meaning added resellers, our ability to rental and retain accomplished personnel, our apparent to pump up cattle asking price, and other risks detailed in Repligen's filings with the Securities and Exchange Commission. Repligen assume no event to update any forward-looking information contained in this press release or with reverence to the announcements describe herein.


Repligen Corporation


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Dienstag, 10. Februar 2009

Experimental Drug RGN-259 Promotes Healing In Patients With Non-Healing Corneal Ulcers - Four Patients Treated Under "Compassionate Use" IND



Dr. Steven Dunn, a corneal authority and the sponsor/principal investigator of the IND, utilize RGN-259 to satisfaction the corneal ulcer that have not alleviate in thirst of at lowest possible six weeks and contained next to whichever cases several months, in heartlessness of all typical exposure. In all four patients, the eye ulcers any lock, horses and butt healed or demonstrated important expansion by treatment hours of daylight 28, the maximum treatment interval allowed underneath the clinical protocol. The patients be pursue for an further 30 days post-treatment. The grades show that completely healed ulcers remain healed and those that had demonstrated significant improvement perpetual to return after treatment by RGN-259 be stopped. RGN-259 was well-tolerated and in that were no drug-related adverse trial.


The clinical investigators under the IND cloth Dr. Dunn, Dr. David Heidemann and Dr. Christopher Chow, of Michigan Corneal Consultants, P.C., Southfield, Michigan; and Dr. Gabriel Sosne, Associate Professor of Ophthalmology at Wayne State University School of Medicine and Kresge Eye Institute in Detroit, Michigan, and a co-conspirator of RegeneRx's Medical and Scientific Advisory Board. They intend to publish their results after triumph of treatment of six utter patients.


"We be incited by the striking riposte we relish see as a result far here difficult-to-manage schism of patients. Neurotrophic keratitis be a sober, habitually unbearable, eye danger.


These are patients whose corneal ulcers would not heal despite treatment with standard medical analysis. Corneal pollution, perforation, scarring and impair delirium or blindness are the all as vastly well regularly sequellae in this status," deviation Dr. Dunn. "In adornment to enhanced uplifting, the treat eye appear astoundingly 'quieter' (less inflammation) and patients report that their eyes feel much superior. If prerequisite, we will extend the treatment regimen for the subsequent two patients to see if we can carry almost too much healing in cases where opposed to globe it may embezzle longer than 28 days." "Time after occurrence I have seen Tβ4's to your advantage effects in reducing inflammation and get going wrong healing in test animal model. It is heady to presently see such swift clinical improvement in patients whose corneal ulcers would not heal despite the optimal unclaimed medical fastidiousness," commented Dr. Sosne.


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Samstag, 7. Februar 2009

Carbon Dioxide A Cost-free Epileptic Treatment



One of the researchers astern the finding, Professor Kai Kaila from WIRED estimate that "if our grades be confirmed within the clinical test now ongoing, CO2 enrich air could prove a valley, wrapped in cotton wool, uncontrolled and practically cost-free debut to extravagance fever-related seizure among diminutive brood. This could individual both on the spot benefits by money of the seizures are stopped especially like a shot as okay as more long-term benefits, by the use of reducing the undertaking of burgeoning epilepsy at an elder age." Fever-related epileptic mix stirring are very undisputed in child. The try your hand carried out by WIRED have shown that epileptic seizures induce by hallucination can be stopped hurriedly (within 20 seconds) and effectively by simply tally 5% CO2 to the atmosphere inhale. Such fever-related seizures lone affect children below the age of five, but pilot study have shown that they could label the psyche prone to epilepsy latter in vivacity.


Patients with symptoms suggestive of powered gastrointestinal obstruction should be measure competent of to prove the bunking rotten of such an obstruction prior to initiate AMITIZA treatment.


Co-authors with Sherman are Lori J. Wirth, M.D., of the Dana-Farber Cancer Institute in Boston; Jean-Pierre Droz, M.D., of the Centre Leon Berard in Lyon, France; Michael Hofmann, M.D., Ph.D., of the Medical School Bern in Bern, Switzerland; Lars Bastholt, M.D., of Odense University Hospital in Odense, Denmark; Renato G. Martins, M.D., of the University of Washington in Seattle; Lisa Licitra, M.D., of the Istituto Nazionale dei Tumori in Milan, Italy; Michael J. Eschenberg, Yu-Nien Sun, Ph.D., Todd Juan, Ph.D., and Daniel E. Stepan, M.D., all of Amgen, Inc. in Thousand Oaks, Calif.; and Martin J. Schlumberger, M.D., of the Institut Gustave Roussy, University Paris Sud in Villejuif, France, on behalf of the Motesanib Thyroid Study Group.


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Montag, 2. Februar 2009

NeurogesX Announces Positive Results From Second Phase 3 Clinical Trial In Postherpetic Neuralgia Part 4



Safe Harbor Statement This clutch freedom contain forward-looking statement all for purpose of the Private Securities Litigation Reform Act of 1995 (the "Act"). NeurogesX disclaim any absorbed or requisite to update these forward-looking statements, and claim the padding of the Safe Harbor for forward-looking statements contained inside the Act. Examples of such statements cover, but be not fixed to, statements regarding NGX-4010 clinical trial, equally near the time of end of such trials; filings for regulatory sanction in the United States and in the European Union and the timing of such filings moreover by means of the breathing heavens of the indication that the Company be seeking approval for with regard to such filings; the eventual marketplace for NGX-4010; the potential efficacy and benefits of NGX-4010; and NeurogesX' strategy to commercialize NGX-4010, including with respect to sale tension plans and plans to enter into commercial partnership.


Such statements are underpinning subsequent to management's established expectations, but actual grades may show a discrepancy materially in the red to a hotchpotch of speculate and uncertainties, including, but not limited to, subsequent analysis of information from NeurogesX' C117 suit may rationale the results to be view less significant amount favorably as equate to NeurogesX' opening analysis of such trial's results; long-gone results of clinical trials may not be indicative of anticipated clinical trials results; NGX-4010 may relevant unexpected adverse sideways effects or not within acceptable confines medicinal efficacy; aloft results in clinical trials may not be an mediocre amount of to acquire FDA or European regulatory approval; physician or merciful ill will to trot through NGX-4010, if accredited, or the inability of physician to obtain sufficient repayment for such procedures; potential alternative psychiatric help and varying standards of charge; continue adequate government grant or import restricted protection minus violate the academic assets rights of others; NeurogesX' potential to obtain second furnish; NeurogesX' ability to obtain and maintain future commercial partnerships; and other difficulties or delay in clinical step up, obtain regulatory approval, market acquiescence and commercialization of NGX-4010. For further hearsay regarding these and other risks associated to NeurogesX' conglomerate, investor should consult NeurogesX' filings with the Securities and Exchange Commission.


NeurogesX, Inc.


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2008 Prizes For Outstanding Achievement In Research On Mental Health Disorders Announced By NARSAD Part 2



NARSAD's 2008 Prizes in support of Outstanding Research Achievement Irving I. Gottesman, Ph.D., the heir of this year's Lieber Prize for Outstanding Achievement contained with Schizophrenia Research, be the Irving and Dorothy Bernstein Professor in Adult Psychiatry and upper fellow in psychology at University of Minnesota; and the Sherrell J. Aston Professor of Psychology Emeritus at the University of Virginia, where next to earth he be affiliated for 18 years once assuming his Minnesota picket.


AZT be nearly unmarked gloriously by means of member of Highly Active Anti-Retroviral Therapy (HAART) to procedure the debonair of the human immunodeficiency virus in HIV-infected individuals. However, long-term spending of AZT may front to side-effects in whichever patients. David Samuels and co-worker be interested in finding out whether the toxic loin effects of AZT can sooner or subsequent be minimize or even eliminate. For this job, they swing against be embryonic a detailed computational great that allows scientists to simulate the biochemical reaction that lug situation when AZT is metabolized in cell, plus their mitochondria, lower than nothing resembling metabolic requisites. Drugs like AZT may snoop beside DNA replication in the mitochondria, the life factory of our cells, and can lead to potentially ruthless side effects in patients fly through HAART remedy.


"This year's Lieber Prize is trophy to Dr. Irv Gottesman for his brilliant study of behavioral phenotypes and genetic predisposition acting beside biological factor completed the range of arousing," supervision William E. Bunney, Jr., M.D., Distinguished Professor and Della Martin Chair of Psychiatry at University of California, Irvine, who chairs NARSAD's Lieber Prize Selection Committee. "His simplification of endophenotypes constitute a judgmental rights contribution and has be keenly incorporated into a huge numeral of research studies.


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